Open post

TransQST present at Science Is Wonderful! exhibition

TransQST work presented at the virtual Science Is Wonderful! exhibition

TransQST researchers of the University of Oxford participated in the European Research and Innovation Days´ virtual exhibition Science Is Wonderful! held on 22-24 of September 2020. Part of the second edition of European Research and Innovation Days, the Science is Wonderful! exhibition aims to bring the world of science, research, and innovation to the public. This year´s exhibition was […]

Read moreMore Tag
Open post

TransQST Webinar series
DisGeNET knowledge management platform:
a key resource to support drug R&D

The DisGeNET knowledge management platform was presented by IMIM researchers

The TransQST Webinar series 2020 was launched on Monday July 6th with an interactive presentation given by Janet Piñero (Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain) on the DisGeNet knowledge management platform for disease genomics.  DisGeNET contains information on genes and variants associated with drug side effects, facilitating drug target identification and toxicity assessment, […]

Read moreMore Tag
Open post

5th General Assembly Meeting

TransQST GAM5 took place as a virtual meeting in April 2020

The TransQST GAM5 was held on 20th and 21st of April 2020 as a 2-day virtual meeting. The sessions were centered around the progress of the models and work carried out within the different Work Packages, as well as future plans and preparation for the project Mid-term Review. Discussions were also held involving possible delays […]

Read moreMore Tag
Open post

Animal Welfare Research Prize 2019 for IfADo toxicologists

Animal Welfare Research Prize 2019 for IfADo toxicologists

Leibniz Research Centre for Working Environment and Human Factors (IfADo) receives the “Animal Welfare Research Prize 2019” by the Federal Ministry of Food and Agriculture of Germany. The Federal Ministry of Food and Agriculture annually awards the “Animal Welfare Research Prize” for outstanding research works that aim to reduce or replace animal experiments in the […]

Read moreMore Tag
Open post

TransQST at SPS

TransQST at Safety Pharmacology Society Annual Meeting

A fantastic representation of the TransQST progress at the Safety Pharmacology Society Annual Meeting held in Barcelona last September, and great success of the Oxford team at the SPS meeting. Two third place awards for poster presentation went to our researchers from Oxford.

Read moreMore Tag
Open post

4rd General Assembly Meeting

TransQST GAM4 took place in Castelldefels (Spain) in september 2019

The forth TransQST General Assembly meeting was held in Castelldefels, Spain on September 19th and 20th, 2019. During the first day, WPs sessions were organised focussed on update discussions. On the second day, the consortium met at the plenary session for the WP progress and achievements. The 2-day meeting focused on the progress of the […]

Read moreMore Tag
Open post

3rd General Assembly Meeting

TransQST GAM3 took place in Ingelheim (Germany) in April 2019

The third TransQST General Assembly meeting was held in BI premises in Ingelheim, Germany, on April 9th and 10th, 2019. During the first day parallel sessions of Organ WPs were organised. On the second day the consortium met at the plenary session for the WP updates and discussion on the next steps. The discussion at […]

Read moreMore Tag
Open post

An innovative WGCNA tool, the TXG-MAPr

UL partner updated their WGCNA tool

The Research Division of Drug Discovery and Safety of the University of Leiden (UL) participates to TransQST consortium. Bob van de Water’s lab team has mined data of the TG-GATEs database on primary human hepatocytes, rat in vivo liver and kidney gene expression data and established WGCNA modules. These modules are available in an open […]

Read moreMore Tag
Open post

TransQST WP7 achievements

Cardiovascular hemodynamic modeling framework

The Leiden University group for WP7 has been working in the last period to obtain in-depth insight into available data across species to support the cardiovascular hemodynamic modeling framework in order to identify gaps that we hope to fill (see figure). Furthermore, the group are currently running identifiability analyses to fully characterize the possible mode […]

Read moreMore Tag
Open post

TransQST at the IMI 10th anniversary

TransQST posters at the IMI 10th anniversary scientific symposium in October 2018

TransQST young researchers presented two posters at the IMI 10th anniversary scientific symposium in October 2018 The Innovative Medicines Initiative celebrated its 10th anniversary in 2018, and several activities took place to mark the occasion, certainly the most prominent one was the Scientific Symposium held on 22nd– 23rd of October in Brussels. During the two […]

Read moreMore Tag
Open post

2nd General Assembly Meeting

TransQST GAM2 took place in Paris (France) in October 2018

The second TransQST General Assembly meeting was held in Sanofi premises in Chilly Mazarin (Paris, France) on the 17th and 18th of October 2018. The consortium members had the opportunity to meet for the first time after the early review that took place in June 2018 and discuss the so-far progress. The TransQST project is […]

Read moreMore Tag
Open post

TransQST poster at the EUROTOX conference

TransQST poster at the EUROTOX in Brussels (Belgium) in September 2018

A poster of the TransQST work contributed by the University of Maastricht partner to the project was presented at the EUROTOX, 2-5th September in Brussels. In addition to the poster session participation, UM colleagues were also invited to present this poster in the Astrazeneca Educational Event, organized in the framework of the conference on the […]

Read moreMore Tag
Open post

TransQST at Drug Safety GRC

TransQST participants attend the 2018 Drug Safety Gordon Research Conference

The TransQST project was well represented at the recent Drug Safety Gordon Research Conference (program).  The meeting addressed contemporary issue in drug safety spanning discovery to post-marketing surveillance with several sessions focused on translational safety and systems modeling.   Jim Stevens (Lilly/Leiden) Chaired the meeting.  Blanca Rodriguez (Oxford) gave a GRC plenary lecture titled, “Computational Modeling […]

Read moreMore Tag
Open post

TransQST Early Review

TransQST Early Review in Brussels (Belgium) in June 2018

On the 14th of June, TransQST consortium presented the progress of the project in the Early Review meeting that took place at the IMI premises The objective of this early review was to show up the strategy defined for the whole consortium to accomplish the goals of the project proposal and to give update on […]

Read moreMore Tag
Open post

TransQST meets eTRANSAFE

TransQST meets eTRANSAFE in Barcelona (Spain) in June 2018

On the 5th of June, TransQST project was presented in the 3rd consortium meeting of the IMI eTRANSAFE project. Professor Bob van de Water, from University of Leiden, presented the TransQST project to the eTRANSAFE consortium in their 3rd consortium meeting held on the 4-5th of June in Barcelona. Both IMI projects work in the […]

Read moreMore Tag
Open post

1st General Assembly Meeting

TransQST GAM1 took place in Vihti (Finland) in April 2018

The first General Assembly meeting, GAM1, took place on the 25th and 26th of April 2018, in Vihti at Orion Tuohilampi Training Center (Finland). This 2-day meeting was organized as follows: Day 1 – paralel meetings of Organ related WPs with representatives of WP3 (data) and WP4 (modelling), and Day 2 – whole consortium meeting […]

Read moreMore Tag
Open post

UOXF TransQST colleagues won the 2017 NC3Rs Prize

An in silico model that predicts cardiotoxicity awarded in March 2018

On the 12th of March 2018, the National Centre for the 3Rs (NC3Rs) – an organisation dedicated to replacing, refining and reducing the use of animals in research and testing – has awarded its top prize for a research paper on an in silico model that predicts cardiotoxicity developed and reported by the TransQST team […]

Read moreMore Tag
Open post

Boehringer Ingelheim joins the TransQST consortium

Boehringer Ingelheim has joined the consortium, effective since July 2017

The Boehringer Ingelheim (BI) pharmaceutical company made a formal proposal to join the TransQST consortium in June 2017. The TransQST partners found their addition to be an excellent opportunity to complement and extend the coverage of the modeling framework within the particular area of GI toxicity assessment (WP8). SYNAPSE has coordinated the documentation preparation between […]

Read moreMore Tag
Open post

2nd Workshop

TransQST 2nd Workshop took place in Ludwigshafen (Germany) in September 2017

The 2nd workshop took place on the 28th and 29th of September 2017, in Ludwigshafen at AbbVie premises (Germany). This workshop was scheduled as follow up on the 1st Workshop, January 2017. The goals of this 2nd workshop were focused on the evaluation that all WPs have been doing during these early months of the […]

Read moreMore Tag
Open post

EAB and SAB members

TransQST announces the Ethics and Scientific Advisory Boards members in July 2017

The TransQST consortium is pleased to announce the members of the TransQST Ethics Advisory Board (EAB) and the TransQST Scientific Advisory Board (SAB). To achieve the TransQST objectives, the consortium will use pre-existing data wherever possible but will, on occasion, require access to human/animal biofluid samples and tissue biopsies in order to back-fill data gaps […]

Read moreMore Tag
Open post

WP5-WP6 Meeting

TransQST WP5-WP6 Meeting was held in Leiden (the Netherlands) in March 2017

WP5 and WP6 joint for a meeting hosted by the University of Leiden on the 24th of March 2017. Representatives of both work packages discussed on the understanding of how and what a multi-scale model is for the Liver (WP5) or Kidney (WP6) organs. This first face-to-face meeting was organized to develop a Roadmap for […]

Read moreMore Tag
Open post

Kick off meeting

TransQST kick off Meeting was held in Barcelona (Spain) in January 2017

The Kick off Meeting of the TransQST project took place on the 23rd and 24th of January 2017 in the city of Barcelona, and counted with the attendance of the representatives of the whole Consortium. The new European five-year research project, Translational Quantitative Systems Toxicology to improve the understanding of the safety medicines (TransQST), was launched […]

Read moreMore Tag
Open post

News Release

€16M cash boost for adverse drug reaction research

A new European research project has been launched which aims to improve the understanding of adverse drug reactions (ADR) and the approach of systems modelling approaches to drug safety. A new €16m European research project has been launched which aims to improve the understanding of adverse drug reactions and the approach of systems modelling approaches […]

Read moreMore Tag