Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Projects. Pastor M, Quintana J, Sanz F. Front. Pharmacol. 2018. 9:1147. Partner involved: IMIM/UPF
Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response Piñero J, Gonzalez-Perez A, Guney E, Aguirre-Plans J, Sanz F, Oliva B, Furlong LI. Front. Genet. 2018 9:412. Partner involved: IMIM
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin on vasoconstriction. Yin A, Yamada A, Stam WB, van Hasselt JGC, van der Graaf PH. Br J Pharmacol. 2018 Jun 2. Partner involved: UL
Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity. Passini E, Britton OJ, Lu HR, Rohrbacher H, Hermans AN, Gallacher DJ, Greig RJH, Bueno-Orovio A, Rodriguez B. Frontiers in Physiology. 2017 Sept 12. Partner involved: UOXF
The work reported in this article has won the 2017 3Rs Prize, awarded by the NC3Rs. More information here
Integration of Genome Scale Metabolic Networks and gene regulation of metabolic enzymes with Physiologically Based Pharmacokinetics. Maldonado EM, Leoncikas V, Fisher CP, Moore JB, Plant NJ, Kierzek AM. CPT Pharmacometrics Syst Pharmacol. 2017 Aug 7. Partner involved: SIMCYP.