This page provides links to publicly accessible outcomes of the Translational Quantitative Systems Toxicology (TransQST) project. As many outcomes might only become accessible after the end of the project, this page focuses on providing query links to public resources, so that results always represent the current status, and continue to be up to date, even if the page is not maintained after the end of the funding period.
Publicly available models either developed by the TransQST consortium, or curated from the literature in the context of the project:
Tools (further) developed and/or utilised by the TransQST consortium:
On request of WP5/6, a comprehensive set of liver/kidney expression datasets has been curated and is available via ArrayExpress. All TransQST datasets have been tagged with text in the dataset Experiment Description stating: “this dataset is part of the TransQST collection”. The datasets are accessible with the query https://www.ebi.ac.uk/arrayexpress/search.html?query=transqst
High quality datasets with further curation are linked to the Expression Atlas Knowledge Base from the rightmost column (“Atlas”) in the above query.
Curation of drug safety data
Serious or life-threatening safety-related information for approved drugs has been curated. Toxicity class(es) have been assigned to approved drugs with black box warning information described on medicinal product labels, and to ‘withdrawn’ drugs that have been approved but subsequently withdrawn from one, or more, markets in the world. Such curated toxicity information allows drugs that cause similarly reported toxicities (e.g. hepatotoxicity, cardiotoxicity, gastrointestinal toxicity, etc) to be easily grouped, analysed and visualised. The curated safety information is available in ChEMBL for drugs with black box warnings, and withdrawn drugs (via link https://www.ebi.ac.uk/chembl/web_components/explore/drug_warnings), with further information published by Hunter et al., 2021. (https://pubs.acs.org/doi/10.1021/acs.chemrestox.0c00296 ).
Other data that has been collected as part of the TransQST project includes histopathology, clinical chemistry, toxicokinetics data, hemodynamic and ion channel data. When this data becomes publicly available, for example when it is published as supporting information to accompany a scientific publication it will become available via this link. (https://www.ebi.ac.uk/biostudies/studies/?facet.collection=transqst)
Scientific publications of TransQST consortium, based on the query GRANT_ID:"116030":