Article 45 Integration of temporal single cell cellular stress response activity

Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury. Wijaya L, Trairatphisan P, Gabor A, Niemeijer M, Keet J, Alcalà A, Snijders K, Wink S, Yang H, Childknecht S, Stevens J, Bouwman P, Kamp H, Hengstler, Beltman J, Leist M, Le Dévédec S, Saez-Rodriguez J, Van de Water B. Biochemical Pharmacology. 2021. 190:114591. Partners involved: UL, UKHD