The work of TransQST members was showcased at the Research Integrity Annual Lecture of the ISMIB (University of Liverpool) on 16th of December by Rahuman Sheriff, BioModels Project Leader at EMBL-EBI. The talk “Reproducibility in Systems Biology Modelling – BioModels’ Role” given at the event is based on a recent article led by the EMBL-EBI […]
Read moreMore TagTransQST 8th General Assembly Meeting
The TransQST Consortium members gathered for the 8th General Assembly Meeting in November
The TransQST Consortium held its bi-annual General Assembly as a virtual meeting on the 15th and 16th of November. The aim of the meeting was to report on the progress of the project, to exchange ideas and discuss upcoming plans, strategies, and activities. After a 6-month no-cost extension requested to the IMI, the project will […]
Read moreMore TagOcellO is Acquired by CrownBio to Complement a Strong Product Portfolio
We are happy to announce the recent acquisition of the TransQST partner OcellO by Crown Bioscience (CrownBio), a JSR Life Sciences global drug discovery and development service company, providing translational platforms to advance oncology, immuno-oncology, and inflammatory disorders. With this acquisition, which will contribute to make both companies stronger and more competitive, CrownBio will officially become […]
Read moreMore TagTransQST 7th General Assembly Meeting
The TransQST Consortium members gathered for the 7th General Assembly Meeting in April
The bi-annual TransQST General Assembly Meeting was hosted in a virtual format for the 3rd time on 12th and 13th of April 2021. The first day of the meeting was dedicated to showcasing how the project has impacted the field of toxicology by improving the understanding of the safety of medicines from different perspectives. Use […]
Read moreMore TagTransQST Webinar Series on Model Implementation
A new hands-on webinar format launched in January 2021
The TransQST consortium is proud to present a new Webinar series on Model Implementation starting on January 26, 2021. The aim of this activity is to catalyse discussions on the implementation of consortium-developed models in the pharma industry as part of the project sustainability. In order to focus the webinars on the right questions and […]
Read moreMore TagTransQST Webinar series – Journal Club by ULIV researchers
A transcriptional response assay for predicting bioactivation-mediated drug-induced liver injury
A new edition of the TransQST Webinar series 2020 took place on Monday November 9th with a presentation delivered by Rowena Sison-Young (ULIV). Accurately predicting the liability of drug candidates to cause hepatotoxicity remains a challenge for the pharmaceutical industry. This is a consequence of the complex nature of this disease which encompasses several mechanisms, […]
Read moreMore Tag6th TransQST General Assembly Meeting
TransQST GAM6 took place as a virtual meeting in October 2020
The 6th TransQST General Assembly Meeting was held on 5th and 6th of October 2020 as a 2-day virtual conference. Close to 100 delegates of the TransQST consortium joined the event, centred on the implementation of the models and work carried out within the different work packages, as well as on defining future dissemination and […]
Read moreMore TagTransQST Webinar series – A guided tour to the use of organoids for compound efficacy and adversity
The latest advances in the use of organoids were brought to TransQST partners and external participants by the OcellO crew.
The TransQST Webinar series 2020 resumed on Monday September 14th with a presentation delivered by the Senior Director of OcellO BV, Bram Herpers, on the use of organoids in drug testing. OcellO is a CRO offering drug testing services in 3D cultured human tissues. OcellO screens, identifies and profiles potential drugs for efficacy and adverse […]
Read moreMore Tag5th General Assembly Meeting
TransQST GAM5 took place as a virtual meeting in April 2020
The TransQST GAM5 was held on 20th and 21st of April 2020 as a 2-day virtual meeting. The sessions were centered around the progress of the models and work carried out within the different Work Packages, as well as future plans and preparation for the project Mid-term Review. Discussions were also held involving possible delays […]
Read moreMore TagAnimal Welfare Research Prize 2019 for IfADo toxicologists
Animal Welfare Research Prize 2019 for IfADo toxicologists
Leibniz Research Centre for Working Environment and Human Factors (IfADo) receives the “Animal Welfare Research Prize 2019” by the Federal Ministry of Food and Agriculture of Germany. The Federal Ministry of Food and Agriculture annually awards the “Animal Welfare Research Prize” for outstanding research works that aim to reduce or replace animal experiments in the […]
Read moreMore TagTransQST at SPS
TransQST at Safety Pharmacology Society Annual Meeting
A fantastic representation of the TransQST progress at the Safety Pharmacology Society Annual Meeting held in Barcelona last September, and great success of the Oxford team at the SPS meeting. Two third place awards for poster presentation went to our researchers from Oxford.
Read moreMore Tag4rd General Assembly Meeting
TransQST GAM4 took place in Castelldefels (Spain) in september 2019
The forth TransQST General Assembly meeting was held in Castelldefels, Spain on September 19th and 20th, 2019. During the first day, WPs sessions were organised focussed on update discussions. On the second day, the consortium met at the plenary session for the WP progress and achievements. The 2-day meeting focused on the progress of the […]
Read moreMore Tag3rd General Assembly Meeting
TransQST GAM3 took place in Ingelheim (Germany) in April 2019
The third TransQST General Assembly meeting was held in BI premises in Ingelheim, Germany, on April 9th and 10th, 2019. During the first day parallel sessions of Organ WPs were organised. On the second day the consortium met at the plenary session for the WP updates and discussion on the next steps. The discussion at […]
Read moreMore TagAn innovative WGCNA tool, the TXG-MAPr
UL partner updated their WGCNA tool
The Research Division of Drug Discovery and Safety of the University of Leiden (UL) participates to TransQST consortium. Bob van de Water’s lab team has mined data of the TG-GATEs database on primary human hepatocytes, rat in vivo liver and kidney gene expression data and established WGCNA modules. These modules are available in an open […]
Read moreMore TagTransQST WP7 achievements
Cardiovascular hemodynamic modeling framework
The Leiden University group for WP7 has been working in the last period to obtain in-depth insight into available data across species to support the cardiovascular hemodynamic modeling framework in order to identify gaps that we hope to fill (see figure). Furthermore, the group are currently running identifiability analyses to fully characterize the possible mode […]
Read moreMore TagTransQST at the IMI 10th anniversary
TransQST posters at the IMI 10th anniversary scientific symposium in October 2018
TransQST young researchers presented two posters at the IMI 10th anniversary scientific symposium in October 2018 The Innovative Medicines Initiative celebrated its 10th anniversary in 2018, and several activities took place to mark the occasion, certainly the most prominent one was the Scientific Symposium held on 22nd– 23rd of October in Brussels. During the two […]
Read moreMore Tag2nd General Assembly Meeting
TransQST GAM2 took place in Paris (France) in October 2018
The second TransQST General Assembly meeting was held in Sanofi premises in Chilly Mazarin (Paris, France) on the 17th and 18th of October 2018. The consortium members had the opportunity to meet for the first time after the early review that took place in June 2018 and discuss the so-far progress. The TransQST project is […]
Read moreMore TagTransQST poster at the SPS conference
TransQST poster at the SPS conference in Washington (US) in October 2018
A poster of the TransQST work contributed by the University of Oxford partner to the project was presented at the Safety Pharmacology Society annual meeting, 30th September – 3rd October in Washington, DC.
Read moreMore TagTransQST poster at the EUROTOX conference
TransQST poster at the EUROTOX in Brussels (Belgium) in September 2018
A poster of the TransQST work contributed by the University of Maastricht partner to the project was presented at the EUROTOX, 2-5th September in Brussels. In addition to the poster session participation, UM colleagues were also invited to present this poster in the Astrazeneca Educational Event, organized in the framework of the conference on the […]
Read moreMore TagTransQST at Drug Safety GRC
TransQST participants attend the 2018 Drug Safety Gordon Research Conference
The TransQST project was well represented at the recent Drug Safety Gordon Research Conference (program). The meeting addressed contemporary issue in drug safety spanning discovery to post-marketing surveillance with several sessions focused on translational safety and systems modeling. Jim Stevens (Lilly/Leiden) Chaired the meeting. Blanca Rodriguez (Oxford) gave a GRC plenary lecture titled, “Computational Modeling […]
Read moreMore TagTransQST Early Review
TransQST Early Review in Brussels (Belgium) in June 2018
On the 14th of June, TransQST consortium presented the progress of the project in the Early Review meeting that took place at the IMI premises The objective of this early review was to show up the strategy defined for the whole consortium to accomplish the goals of the project proposal and to give update on […]
Read moreMore TagTransQST meets eTRANSAFE
TransQST meets eTRANSAFE in Barcelona (Spain) in June 2018
On the 5th of June, TransQST project was presented in the 3rd consortium meeting of the IMI eTRANSAFE project. Professor Bob van de Water, from University of Leiden, presented the TransQST project to the eTRANSAFE consortium in their 3rd consortium meeting held on the 4-5th of June in Barcelona. Both IMI projects work in the […]
Read moreMore Tag1st General Assembly Meeting
TransQST GAM1 took place in Vihti (Finland) in April 2018
The first General Assembly meeting, GAM1, took place on the 25th and 26th of April 2018, in Vihti at Orion Tuohilampi Training Center (Finland). This 2-day meeting was organized as follows: Day 1 – paralel meetings of Organ related WPs with representatives of WP3 (data) and WP4 (modelling), and Day 2 – whole consortium meeting […]
Read moreMore TagUOXF TransQST colleagues won the 2017 NC3Rs Prize
An in silico model that predicts cardiotoxicity awarded in March 2018
On the 12th of March 2018, the National Centre for the 3Rs (NC3Rs) – an organisation dedicated to replacing, refining and reducing the use of animals in research and testing – has awarded its top prize for a research paper on an in silico model that predicts cardiotoxicity developed and reported by the TransQST team […]
Read moreMore TagBoehringer Ingelheim joins the TransQST consortium
Boehringer Ingelheim has joined the consortium, effective since July 2017
The Boehringer Ingelheim (BI) pharmaceutical company made a formal proposal to join the TransQST consortium in June 2017. The TransQST partners found their addition to be an excellent opportunity to complement and extend the coverage of the modeling framework within the particular area of GI toxicity assessment (WP8). SYNAPSE has coordinated the documentation preparation between […]
Read moreMore Tag2nd Workshop
TransQST 2nd Workshop took place in Ludwigshafen (Germany) in September 2017
The 2nd workshop took place on the 28th and 29th of September 2017, in Ludwigshafen at AbbVie premises (Germany). This workshop was scheduled as follow up on the 1st Workshop, January 2017. The goals of this 2nd workshop were focused on the evaluation that all WPs have been doing during these early months of the […]
Read moreMore TagEAB and SAB members
TransQST announces the Ethics and Scientific Advisory Boards members in July 2017
The TransQST consortium is pleased to announce the members of the TransQST Ethics Advisory Board (EAB) and the TransQST Scientific Advisory Board (SAB). To achieve the TransQST objectives, the consortium will use pre-existing data wherever possible but will, on occasion, require access to human/animal biofluid samples and tissue biopsies in order to back-fill data gaps […]
Read moreMore TagWP5-WP6 Meeting
TransQST WP5-WP6 Meeting was held in Leiden (the Netherlands) in March 2017
WP5 and WP6 joint for a meeting hosted by the University of Leiden on the 24th of March 2017. Representatives of both work packages discussed on the understanding of how and what a multi-scale model is for the Liver (WP5) or Kidney (WP6) organs. This first face-to-face meeting was organized to develop a Roadmap for […]
Read moreMore TagKick off meeting
TransQST kick off Meeting was held in Barcelona (Spain) in January 2017
The Kick off Meeting of the TransQST project took place on the 23rd and 24th of January 2017 in the city of Barcelona, and counted with the attendance of the representatives of the whole Consortium. The new European five-year research project, Translational Quantitative Systems Toxicology to improve the understanding of the safety medicines (TransQST), was launched […]
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