TransQST GAM4 took place in Castelldefels (Spain) in september 2019

The forth TransQST General Assembly meeting was held in Castelldefels, Spain on September 19th and 20th, 2019.

During the first day, WPs sessions were organised focussed on update discussions. On the second day, the consortium met at the plenary session for the WP progress and achievements. The 2-day meeting focused on the progress of the models.

Great scientific discussions were scheduled around planning for the mid-term review, scheduled for June 2020.

A poster session took place at the end of the first day, which supported the main results generated within the project; the following posters were presented:

1- Hemodynamic systems model to characterize cardiovascular drug effects – Yu Fu, N. Snelder, H. Taghvafard, P.H. van der Graaf, J.G.C. van Hasselt

2- Hemodynamic simulator: A shiny web application for predicting drug effect on hemodynamics – Yu Fu, N. Snelder, P.H. van der Graaf, J.G.C. van Hasselt

3- Contextualization of causal regulatory signalling networks from gene expression data and its applications to drug-induced liver injury (DILI)- Panuwat Trairatphisan, Terezinha Maria de Souza Jos Kleinjans, Danyel Jennen, Julio Saez-Rodriguez

4- Physiologically Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) model of gastrointestinal toxicity induced by 5-fluorouracil in mouse and translation to human – Sofia Ferreira, Mian Zhang, Dan Liu, Iain Gardner

5- Dosing corrected for species differences in toxicokinetics using PBPK modelling predicts equivalent reactive metabolite burden following acetaminophen overdose – D. Reddyhoff, R. Sison-Young, L. Livoti, G. Vermeil De Conchard, Y. Parmentier, R. J.Weaver, K. Park, C. Fisher, I. Gardner, I. Copple

6- Development of a permeability-limited cardiac physiologically-based pharmacokinetic model for predicting cardiac exposure – Zofia Tylutki, Ciarán Fisher, Mark Holbrook, Sebastian Polak

7- Hepatocyte core metabolism model coupled with PBPK characterizes effect of valproic acid on lipid metabolism – Vipul Gupta, Christian Maass, Andrzej Kierzek, Jeremy Craven, Ciarán Fisher

8- BioModels Parameters A resource to search and access parameters from published systems models – Chinmay Arankalle, Mihai Glont, Tung Nguyen, Henning Hermjakob, Rahuman S. Malik-Sheriff

9- Toxicogenomic-based gene co-expression network analysis for quantitative mode-of-action assessment of chemical-induced organ toxicity – Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Jennifer Mollon, Yue W. Webster, Panuwat Trairatphisan, Solène Grosdidier, Emre Guney, Janet Piñero Gonzalez, James L. Steven, Bob van de Water

10- Transcriptomic approach to improve the understanding of 5- fluorouracil (5-FU) induced intestinal toxicity in vitro and in vivo – Daniela Rodrigues, Terezinha de Souza, Luke Coyle, Yannick Schrooders, Ferran Jardi, Sandra de Jonghe, Marjolein van Heerden, Lieve Lammens, Danyel Jennen, Jos C.S. Kleinjans, Theo M. de Kok

11- iPATH: a tool to identify drug toxicity pathways based on graph theoretical optimization on the human interactome – Emre Guney, Janet Piñero, Joaquim Aguirre-Plans, Ferran Sanz, Baldo Oliva and Laura I. Furlong

12- Supporting drug toxicity assessment with DisGeNET – Janet Piñero, Ferran Sanz, and Laura I. Furlong

13- Generation of a 5-Fluorouracil Mouse Dataset to Construct a Multi-Scale Predictive Model of Drug-Induced Intestinal Toxicity – Ferran Jardí A, Marjolein Van Heerden A, Daniela Rodrigues B, Jos C.S. Kleinjans B, Theo M. de Kok B, Sofia Ferreira C, Iain Gardner C, Ciaran Fisher c, Mark Pritchard D, Anthony Lynch E, Daniel Sevin E, Kylie Beattie E, Carmen Pin F, Lieve Lammens A and Sandra De Jonghe A

14- Human in Silico Drug Trials with a Novel Human Ventricular Electrophysiology Model – Elisa Passini, Jakub Tomek, Alfonso Bueno-Orovio, Xin Zhou, Blanca Rodriguez

15 – Modelling intestinal toxicity using in vitro 3D gut cultures – Colette Kelly, Harvey Fowler-Williams, Carrie Duckworth and Mark Pritchard

16- Combinatorial Investigation of BAC-GFP HepG2 Reporters of Stress Response Pathways with Logic-ODE modelling Revealing the Mechanisms of Drug Induced Liver Injury – Lukas Surya Wijaya, Panuwat Trairatphisan, Attila Gabor, Marije Niemeijer, Jason Keet, Kirsten Snijders, Ariadna Alcalà Morera,  Steven Wink, Huan Yang, Joost Beltman, Sylvia Le Dévédec, Julio Saez-Rodriguez, Bob van de Water