TransQST posters at the IMI 10th anniversary scientific symposium in October 2018

TransQST young researchers presented two posters at the IMI 10th anniversary scientific symposium in October 2018

The Innovative Medicines Initiative celebrated its 10th anniversary in 2018, and several activities took place to mark the occasion, certainly the most prominent one was the Scientific Symposium held on 22nd– 23rd of October in Brussels. During the two full days, young scientists were in the spotlight, showcasing the IMI projects stellar science and great scientific output that the IMI projects have delivered in the last ten years. The event featured 72 posters and 28 oral presentations, clustered around four topics.

Rowena Sison-Young (ULIV): presented ‘Integration of models of drug-induced liver injury for risk assessment’ poster. The poster focussed on translatability of acetaminophen (APAP) response across species as well as in vitro versus in vivo, ensuring that these were reflected in the computational models being developed. It described in vitro and in vivo APAP work on human, mouse and rat and how it is being used for parameterising the APAP PBPK model that is currently being built within TransQST, as well as assist in the development of new ‘omics based computational models.

Emre Guney (IMIM) presented a poster entitled “Network-based modelling of APAP-induced hepatotoxicity using interactomics and transcriptomics data”, showing the characterisation of the biological pathways activated in human liver in response to APAP (paracetamol) treatment. iPath was presented, a systems biology approach in which tissue-specific interactomics data and drug-induced transcriptomics changes are combined to identify pathways involved in APAP-induced hepatotoxicity.

Both Rowena Sison-Young and Emre Guney agree that the event was a great opportunity to learn about wide breadth of research areas of exciting IMI projects, but also to meet new scientists and points of contacts for scientific exchange.