Forschungsgesellschaft für Arbeitsphysiologie und Arbeitsschutz e.V. (IFADO). Leibniz Research Center (IFADO) is specialized in Toxicology, Systems Biology, Immunology and Neurosciences. The Systems Toxicology Department focusses on spatio-temporal models, modelling of organelles as well as integrated forms that include PBPK or metabolic simulations in spatio-temporal models, which allows an improved quantitative prediction of organ toxicity. In vitro systems for hepatotoxicity testing represent a well-accepted and widely applied tool in pharmacology and toxicology. This group is also member of the steering team of the EU-project EUToxRisk21 and one of the organizers of the Systems Biology Network The Virtual Liver and its successor Liver Systems Medicine (LiSyM).