A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug-induced toxicity. Gall L, Jardi F, Lammens L, Piñero J, Souza TM, Rodrigues D, Jennen DGJ, de Kok TM, Coyle L, Chung SW, Ferreira S, Jo H, Beattie KA, Kelly C, Duckworth CA, Pritchard DM, Pin C. CPT Pharmacometrics Syst Pharmacols. 2023. Online ahead of print. Partner involved: AZ, Janssen, IMIM, UM, BI, Certara, GSK, ULIV
Accurate in silico simulation of the rabbit Purkinje fiber electrophysiological
assay to facilitate early pharmaceutical cardiosafety assessment: Dream
or reality?. Mohr M, Chambard JM, Ballet V, Schmidt F. Pharmacological and Toxicological Methods. 2022. 115:107172. Partner involved: SANOFI
Parallel ant colony optimization for the training of cell signaling networks. González P, Prado-Rodriguez R, Gábor A, Saez-Rodriguez J, Banga JR, Doallo R. Expert Systems With Applications. 2022. 208. Partner involved: UKHD
Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants. Jardi F, Kelly C, Teague C, Fowler-Williams H, Sevin DC, Rodrigues D, Jo H, Ferreira S, Herpers B, Van Heerden M, de Kok T, Pin C, Lynch A, Duckworth CA, De Jonghe S, Lammens L, Pritchard DM. Archives of Toxicology. 2022. Online ahead of print. Partner involved: Janssen, ULIV, UM, CB, AZ
Benchmarking post-GWAS analysis tools in major depression: Challenges and implications. Pérez-Granado J, Piñero J, Furlong LI. Frontiers Genetics. 2022. 13:1006903. Partner involved: IMIM
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac purkinje cells for proarrhythmia risk prediction. Trovato C, Mohr M, Schmidt F, Passini E, Rodriguez B. Toxicology Letters. 2022. 4:992650. Partner involved: UOXF
Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Rodrigues D, van Kampen R, van Bodegraven AA, Kleinjans JCS, Jennen DGJ, de Kok TM. Toxicology Letters. 2022. 371:17-24. Partner involved: UM
Functional Genomics Analysis to Disentangle the Role of Genetic Variants in Major Depression. Heldring MM, Wijaya LS, Niemeijer M, Yang H, Lakhal T, Le Dévédec SE, van de Water B, Beltman JB. Genes journal. 2022. 13(7):1259. Partner involved: IMIM
Model-based translation of DNA damage signaling dynamics across cell types. Heldring MM, Wijaya LS, Niemeijer M, Yang H, Lakhal T, Le Dévédec SE, van de Water B, Beltman JB. PLOS Computational Biology. 2022. 18(7):e1010264. Partner involved: UL
Addressing barriers in comprehensiveness, accessibility, reusability, interoperability and reproducibility of computational models in systems biology. Niarakis A, Waltemath D, Glazier J, Schreiber F, Keating SM, Nickerson D, Chaouiya C, Siegel A, Noël V, Hermjakob H, Helikar T, Soliman S, Calzone L. Briefings in Bioinformatics. 2022. 23(4):bbac212. Partner involved: EMBL