KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study. Füzi B, Malik-Sheriff RS, Manners EJ, Hermjakob H, Ecker GF. Journal of Cheminformatics. 2022. 14(1):37. Partner involved: UNIVIE
Sex-based difference in the effect of metoprolol on heart rate and bradycardia in a population-based setting. Hendriksen LC, Omes-Smit G, Koch BCP, Ikram MA, Stricker BH, Visser LE. Journal of Personalized Medicine. 2022. 12(6):870. Partner involved: EMC
A novel cardiovascular systems model to quantify drugs effects on the inter-relationship between contractility and other hemodynamic variables. Fu Y, Taghvafard H, Said MM, Rossman EI, Collins TA, Billiald-Desquand S, Leishman D, van der Graaf PH, van Hasselt JGC, Snelder N. A novel cardiovascular systems model to quantify drugs effects on the inter-relationship between contractility and other hemodynamic variables. Pharmacometrics & Systems Pharmacology. 2022. 11(5):640-652. Partner involved: UL, AZ, Eli-Lilly
A transcriptomic approach to elucidate the mechanisms of gefitinib-induced toxicity in healthy human intestinal organoids. Rodrigues D, Herpers B, Ferreira S, Jo H, Fisher C, Coyle L, Chung SW, Kleinjans JCS, Jennen DGJ, de Kok TM. International Journal of Molecular Sciences. 2022. 23(4):2213. Partners involved: UM, CB, SIMCYP, BI
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid. Vrijenhoek NG, Wehr MM, Kunnen SJ, Wijaya LS, Callegaro G, Moné MJ, Escher SE, Van de Water B. Journal ALTEX. 2022. 39(2):207–220. Partner involved: UL
Unravelling mechanisms of doxorubicin-induced toxicity in 3D human intestinal organoids. Rodrigues D, Coyle L, Füzi B, Ferreira S, Jo H, Herpers B, Chung S-W, Fisher C, Kleinjans J, Jennen D, de Kok. International Journal of Molecular Sciences. 2022. 23(3):1286. Partner involved: UM
Transcriptomic cross-species analysis of chronic liver disease reveals consistent regulation between humans and mice. Holland C, Ramirez R, Myllys M, Hassan R, Edlund K, Hofmann U, Marchan R, Cadenas C, Reinders J, Hoehme S, Seddek A, Dooley S, Keitel V, Godoy P, Begher-Tibbe B, Trautwein C, Rupp C, Mueller S, Longerich T, Hengstler J. Hepatology Communications. 2022. 6(1):161-177. Partners involved: IFADO, UKHD
Flame: an open source framework for model development, hosting, and usage in production environments. Pastor M, Gómez-Tamayo J, Sanz F. Journal of Cheminformatics. 2021. 13(1):1-15. Partner involved: IMIM
SARS-CoV-2-Specific Antibody Profiles Distinguish Patients with Moderate from Severe COVID-1. de Campos-Mata L, Vaquero ST, Tachó-Piñot R, Piñero J, Grasset EK, Aldea IA, Melero NR, Carolis C, Horcajada JP, Cerutti A, Villar-García J, Magri G. Clinical & Translational Immunology . 2021. 10(9): e1339. Partner involved: IMIM
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility. Musuamba FT, Skottheim Rusten I, Lesage R, Russo G, Bursi R, Emili L, Wangorsch G, Manolis E, Karlsson KE, Kulesza A, Courcelles E, Boissel JP, Rousseau CF, Voisin EM, Alessandrello R, Curado N, Dall'ara E, Rodriguez B, Pappalardo F, Geris L. Pharmacometrics & Systems Pharmacology. 2021. 10(8):804-825. Partner involved: UOXF