In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment. Margara F, Wang ZJ, Levrero-Florencio F, Santiago A, Vázquez M, Bueno-Orovio A, Rodriguez B. Progress in Biophysics and Molecular Biology. 2020. 159: 58-74. Partner involved: UOXF
Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells. Lucendo-Villarin B, Nell P, Hellwig B, Filis P, Feuerborn D, O'Shaughnessy PJ, Godoy P, Rahnenführer J, Hengstler JG, Cherianidou A, Sachinidis A, Fowler PA, Hay DC. EXCLI Journal. 2020 19:1459-1476. Partner involved: IFADO
BioModels-15 years of sharing computational models in life science. Rahuman S. Nucleic Acids Research. 2020. 48(D1):D407-D4. Partner involved: EMBL
The DisGeNET knowledge platform for disease genomics: 2019 update. Piñero J, Ramírez-Anguita M, Saüch-Pitarch J, Ronzano F, Furlong L, Sanz F. Nucleic Acids Research. 2020. 48(1):D845–D855. Partner involved: IMIM
QTc-interval prolongation and increased risk of sudden cardiac death associated with hydroxychloroquine. Ahmadizar F, Soroush N, Ikran A, Kors J, Kavousi M, Stricker B. European Journal of Preventive Cardiology. 2020. 28(17):1875-1882. Partner involved: EMC
Converting networks to predictive logic models from perturbation signalling data with CellNOpt. Gjerga E, Trairatphisan P, Gabor A, Koch H, Chevalier C, Ceccarelli F, Dugourd A, Mitsos A, Saez-Rodriguez J. Bioinformatics. 2020. 36(16):4523-4524. Partners involved: UKHD, Abbvie
BioModels Parameters: a treasure trove of parameter values from published systems biology models. Glont M, Chinmay Arankalle C, Tiwari K, Nguyen T, Hermjakob H, Malik-Sheriff R. Bioinformatics. 2020. 36(17):4649-4654. Partner involved: EMBL
Galaxy InteractoMIX: an integrated computational platform for the study of protein-protein interaction data. Mirela-Bota P, Aguirre-Plans J, Meseguer A, Galletti C, Segura J, Planas-Iglesias J, Garcia-Garcia J, Guney E, Oliva B, Fernandez-Fuentes N. Journal of Molecular Biology. 2020. 433(11):166656. Partner involved: IMIM
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. Buhl E, Djudjaj S, Klinkhammer B, Ermert K, Puelles V, Lindenmeyer M, Cohen C, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber T, Olson L, Floege J, Boor P. EMBO Molecular Medicine. 2020. 12:e11021. Partner involved: UKHD
Blinded in silico drug trial reveals the minimum set of ion channels for torsades de pointes risk assessment. Zhou X, Qu Y, Passini E, Bueno-Orovio A, Liu Y, Vargas H, Rodriguez B. Frontiers in Pharmacology. 2020. 10:1643. Partner involved: UOXF