All-optical electrophysiology refines populations of in silico human iPSC-CMs for drug evaluation. Paci M, Passini E, Klimas A, Severi S, Hyttinen J, Rodriguez B, Entcheva E. Biophysical Journal. 2019. 118(10):2596-2611. Partner involved: UOXF
Capturing variation impact on molecular interactions in the IMEx Consortium mutations data set. Del-Toro N, Duesbury M, Koch M, Perfetto L, Shrivastava A, Ochoa D, Wagih O, Piñero J, Kotlyar M, Pastrello C, Beltrao P, Furlong L, Jurisica I, Hermjakob H, Orchard S, Porras P. Nature Communications. 2019. 10(1):10. Partners involved: EMBL-EBI, IMIM
Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure. Leishman D. Journal of Pharmacological and Toxicological Methods. 2019. 101:106654. Partner involved: Eli-Lilly
From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL. Liu A, Trairatphisan P, Gjerga E, Didangelos A, Barratt J, Saez-Rodriguez J. NPJ Systems Biology Applications. 2019. 5:40. Partner involved: UKHD
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block. Tomek J, Bueno-Orovio A, Passini E, Zhou X, Minchole A, Britton O, Bartolucci C, Severi S, Shrier A, Virag L, Varro A, Rodriguez B. eLife. 2019. 8:e48890. Partner involved: UOXF
Drug‐induced shortening of the electromechanical window is an effective biomarker for in silico prediction of clinical risk of arrhythmias. Passini E, Trovato C, Morissette P, Sannajust F, Bueno‐Orovio A, Rodriguez B. British Journal Pharmacology. 2019. 176(19):3819–3833. Partner involved: UOXF
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Albrecht W, Kappenberg F, Brecklinghaus T. Archives of Toxicology. 2019. 93:1609. Partner involved: IFADO
GUILDify v2.0: A tool to identify molecular networks underlying human diseases, their comorbidities and their druggable targets. Aguirre-Plans J, Piñero J, Sanz F, Furlong LI, Fernandez-Fuentes N, Oliva B, Guney E. Journal of Molecular Biology. 2019. 431(13):2477-2484. Partner involved: IMIM
Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches. Rodrigues D, Souza T, Jennen D, Lemmens L, Kleinjans J, de Kok T. Cancer Treatment Reviews. 2019. 77:57-66. Partners involved: UM, Janssen
Proximal pathway enrichment analysis for targeting comorbid diseases via network endopharmacology. Aguirre-Plans J, Piñero J, Menche J, Sanz F, Furlong L, Schmidt H, Oliva B, Guney E. Pharmaceuticals. 2018. 11(3):61. Partners involved: IMIM, UM