Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches. Rodrigues D, Souza T, Jennen D, Lemmens L, Kleinjans J, de Kok T. Cancer Treatment Reviews. 2019. 77:57-66. Partners involved: UM, Janssen
Proximal pathway enrichment analysis for targeting comorbid diseases via network endopharmacology. Aguirre-Plans J, Piñero J, Menche J, Sanz F, Furlong L, Schmidt H, Oliva B, Guney E. Pharmaceuticals. 2018. 11(3):61. Partners involved: IMIM, UM
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury. Copple I, Den Hollander W, Callegaro G. Archives of Toxicology. 2018. 93:1-15. Partner involved: ULIV
Embracing the dark side: Computational approaches to unveil the functionality of genes lacking biological annotation in drug-induced liver injury. Souza T, Trairatphisan P, Piñero J, Furlong LI, Saez-Rodriguez J, Kleinjans J, Jennen D. Frontiers in Genetics. 2018. 9:527. Partners involved: IMIM, UKA, UM
In Silico models in drug development: where we are. Piñero J, Furlong L, Sanz F. Current Opinion in Pharmacology. 2018. 42:111-121. Partner Involved: IMIM
Development of an infrastructure for the prediction of biological endpoints in industrial environments. Lessons learned at the eTOX projects. Pastor M, Quintana J, Sanz F. Frontiers in Pharmacology. 2018. 9:1147. Partners involved: IMIM
Network, transcriptomic and genomic features differentiate genes relevant for drug response Piñero J, Gonzalez-Perez A, Guney E, Aguirre-Plans J, Sanz F, Oliva B, Furlong L. Frontiers in Genetics. 2018. 9:412. Partner involved: IMIM
Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin on vasoconstriction.
Yin A, Yamada A, Stam W, Van Hasselt J, Van der Graaf P. British Journal Pharmacology. 2018. 175(16):3394-3406. Partner involved: UL
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity. Passini E, Britton O, Lu H, Rohrbacher H, Hermans A, Gallacher D, Greig R, Bueno-Orovio A, Rodriguez B. Frontiers in Physiology. 2017. Partner involved: UOXF |
The work reported in this article has won the 2017 3Rs Prize, awarded by the NC3Rs. More information here
Integration of genome scale metabolic networks and gene regulation of metabolic enzymes with physiologically based pharmacokinetics. Maldonado E, Leoncikas V, Fisher C, Moore J, Plant N, Kierzek A. CPT Pharmacometrics Systems Pharmacology. 2017. 6(11):732-746. Partner involved: SIMCYP